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Ionic facelift


Ionic channels play an important role in the generation of action potential in cells.Mitochondria are essential to the growth and function of all cells and accomplish a multitude of metabolic tasks.The voltage difference in electrical potential across cell membranes is called membrane potential (Cooper, Hausman, Ch 13).Imbedded in this membrane are channels that allow for communications in and out of the cell.Membrane potential arises from the interaction of ion channels and ion pumps that are embedded in the membrane, which maintain different ion concentrations on the intracellular and extracellular sides of a cell membrane.Their revolutionary discoveries sanctioned further studies towards understanding the effect of defective ion channel regulation in the presence of disease as well as toxic substances.The opening and closing of these channels are carefully regulated in order to influence cell function under normal and pathological conditions.3 Single molecules or complexes of molecules within the channels allow for the passage of positively and negatively charged atoms (ions) such as sodium, potassium, chloride and calcium.Our body has 250 different cells containing specific genes tailored to meet the requirements of each cell.5 There can be as many as 500 to 2000 mitochondria scattered throughout the cytoplasm of a cell.This enabled them to confirm and study the regulation of ion channels that influences the life of the cell and its functions (Physiology of Medicine).Ionic channels are very minute and arduous to measure.It is the body’s own electrical system that provides the voltage for ionic exchanges across the cell membranes allowing for cell functions including the intake of nutrients from the blood, removal of cellular waste and movement of impulses along nerve pathways.1 The harmonious flow of these tiny electrical signals is also essential for healthy cell function and cell-to-cell communication.


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